Elevated levels of TRAIL in systemic lupus erythematosus are associated to the presence of anti-SSA/SSB antibodies
Identifieur interne : 001B53 ( Main/Exploration ); précédent : 001B52; suivant : 001B54Elevated levels of TRAIL in systemic lupus erythematosus are associated to the presence of anti-SSA/SSB antibodies
Auteurs : G. Castellino [Italie] ; F. Corallini [Italie] ; F. Trotta [Italie] ; P. Secchiero [Italie]Source :
- Lupus [ 0961-2033 ] ; 2007-07.
English descriptors
- Teeft :
- Apoptosis, Apoptotic, Apoptotic cells, Autoantibody, Castellino, Clinical manifestations, Control subjects, Cytokine, Disease activity, Elisa, Erythematosus, Experimental medicine, Ferrara, Healthy volunteers, High levels, Higher levels, Immunol, Inactive disease, Ligand, Lupus, Maximum values, Neutropenia, Neutrophil, Osteoprotegerin, Peripheral blood, Potential involvement, Present study, Receptor, Serum levels, Serum trail, Serum trail levels, Soluble receptor, Subset, Systemic, Systemic lupus erythematosus, Trail levels, Trail serum levels.
Abstract
The objective of this study was to determine potential relationship between the levels of serum TNF-related apoptosis inducing ligand (TRAIL) and osteoprotegerin (OPG) and clinical markers in systemic lupus erythematosus (SLE) patients. Forty SLE patients with inactive disease were enrolled in this study. For comparison, 20 Sjögren's syndrome (SS) patients and 30 normal controls were also analysed. Serum levels of TRAIL and OPG were determined by ELISA. Serum TRAIL and OPG concentrations in SLE patients were significantly (P < 0.05) higher than those in healthy volunteers. Of note, serum TRAIL but not OPG was significantly (P < 0.05) higher in the SLE patient subset characterized by the presence of anti-SSA/SSB antibodies. The relationship between high levels of TRAIL and SSA/SSB antibodies was further supported by the analysis of SS patients characterized by SSA/SSB antibodies positivity, in which TRAIL levels resulted comparable to the subgroup of anti-SSA/SSB positive SLE patients. The presence of SSA/SSB antibodies, targeting a specific subset of SLE and SS patients, is related to increased serum levels of TRAIL but not of OPG. Lupus (2007) 16, 479—482.
Url:
DOI: 10.1177/0961203307079455
Affiliations:
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Trotta</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Rheumatology Section, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author wicri:is="90%"><name sortKey="Secchiero, P" sort="Secchiero, P" uniqKey="Secchiero P" first="P." last="Secchiero">P. Secchiero</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Human Anatomy Section, Department of Morphology and Embriology, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Lupus</title><idno type="ISSN">0961-2033</idno><idno type="eISSN">1477-0962</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage UK: London, England</pubPlace><date type="published" when="2007-07">2007-07</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="479">479</biblScope><biblScope unit="page" to="482">482</biblScope></imprint><idno type="ISSN">0961-2033</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0961-2033</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Apoptosis</term><term>Apoptotic</term><term>Apoptotic cells</term><term>Autoantibody</term><term>Castellino</term><term>Clinical manifestations</term><term>Control subjects</term><term>Cytokine</term><term>Disease activity</term><term>Elisa</term><term>Erythematosus</term><term>Experimental medicine</term><term>Ferrara</term><term>Healthy volunteers</term><term>High levels</term><term>Higher levels</term><term>Immunol</term><term>Inactive disease</term><term>Ligand</term><term>Lupus</term><term>Maximum values</term><term>Neutropenia</term><term>Neutrophil</term><term>Osteoprotegerin</term><term>Peripheral blood</term><term>Potential involvement</term><term>Present study</term><term>Receptor</term><term>Serum levels</term><term>Serum trail</term><term>Serum trail levels</term><term>Soluble receptor</term><term>Subset</term><term>Systemic</term><term>Systemic lupus erythematosus</term><term>Trail levels</term><term>Trail serum levels</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to determine potential relationship between the levels of serum TNF-related apoptosis inducing ligand (TRAIL) and osteoprotegerin (OPG) and clinical markers in systemic lupus erythematosus (SLE) patients. Forty SLE patients with inactive disease were enrolled in this study. For comparison, 20 Sjögren's syndrome (SS) patients and 30 normal controls were also analysed. Serum levels of TRAIL and OPG were determined by ELISA. Serum TRAIL and OPG concentrations in SLE patients were significantly (P < 0.05) higher than those in healthy volunteers. Of note, serum TRAIL but not OPG was significantly (P < 0.05) higher in the SLE patient subset characterized by the presence of anti-SSA/SSB antibodies. The relationship between high levels of TRAIL and SSA/SSB antibodies was further supported by the analysis of SS patients characterized by SSA/SSB antibodies positivity, in which TRAIL levels resulted comparable to the subgroup of anti-SSA/SSB positive SLE patients. The presence of SSA/SSB antibodies, targeting a specific subset of SLE and SS patients, is related to increased serum levels of TRAIL but not of OPG. Lupus (2007) 16, 479—482.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Castellino, G" sort="Castellino, G" uniqKey="Castellino G" first="G." last="Castellino">G. Castellino</name></noRegion><name sortKey="Corallini, F" sort="Corallini, F" uniqKey="Corallini F" first="F." last="Corallini">F. Corallini</name><name sortKey="Secchiero, P" sort="Secchiero, P" uniqKey="Secchiero P" first="P." last="Secchiero">P. Secchiero</name><name sortKey="Trotta, F" sort="Trotta, F" uniqKey="Trotta F" first="F." last="Trotta">F. Trotta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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